Spironolactone

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Spironolactone and Chf

• Objective: To assess the impact of interventions to increase the use of spironolactone in patients with congestive heart failure (CHF) due to ventricular systolic dysfunction. • Methods: Charts of patients admitted to the medicine department of a single hospital with a primary diagnosis of class IV CHF and left ventricular ejection fraction of 40% or less were randomly selected and reviewed. ...

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Spironolactone and diabetic ketoacidosis.

Introduction Spironolactone is a specific competitive antagonist of aldosterone, the most potent endogenous mineralocorticoid, which modifies renal electrolyte handling and is therefore commonly used as a diuretic in conditions associated with secondary hyperaldosteronism. In renal insufficiency, aldosterone antagonists may induce significant hyperkalaemia even if administered concurrently with...

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Spironolactone-Induced Unilateral Gynecomastia

Gynecomastia is benign enlargement of male breast, drug-induced gynecomastia accounts for about 25%. We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness and easy fatigability. Investigations revealed hypokalemia; he was advised to stop hydrochloroth...

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Spironolactone-associated hyponatremic coma.

Dr. Michael M. Hirschl, Department of Emergency Medicine, New General Hospital, Währinger Gürtel 18-20, A-1090 Vienna (Austria) Admission Dear Sir, Hyponatremia is the most common electrolyte abnormality observed in a general hospitalized population, seen in about 2% of patients [1]. Common causes of hyponatremia are the syndrome of inappropriate secretion of antidiuretic hormone, water intoxic...

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Spironolactone in resistant hypertension.

Spironolactone in Resistant Hypertension To the Editor: The recent article by Chapman1 and the accompanying editorial by Goodfriend2 provide an evidence base for an increased use of spironolactone in patients with resistant hypertension. The usual definition of resistant hypertension states that a diuretic should have been included in the regimen of 3 or more drugs. In this Anglo-Scandinavian C...

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ژورنال

عنوان ژورنال: Journal of Pain and Symptom Management

سال: 2017

ISSN: 0885-3924

DOI: 10.1016/j.jpainsymman.2016.12.320